Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast
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منابع مشابه
Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast
BACKGROUND The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one of the most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme to model gene or antibody - directed enzyme-prodrug therapy (GDEPT/ADEPT) aiming to improve the therapeutic ratio (benefit versus toxic side-effects) of...
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ژورنال
عنوان ژورنال: BMC Biotechnology
سال: 2008
ISSN: 1472-6750
DOI: 10.1186/1472-6750-8-68